Pathology | Research and Innovation

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Contact the Department of Pathology

  • 617-355-7431

Our Current Research Efforts

  • Biology and genomics of pediatric gliomas
  • Classification of acute myeloid leukemia (AML) and specifically clinical significance of dysplasia in AML
  • Clinical significance and cytogenetic findings in mixed phenotype acute leukemia (MPAL)
  • Clinicopathologic features of pediatric gastrointestinal diseases including celiac disease and idiopathic inflammatory bowel disease.
  • Clinicopathologic features of sporadic and syndromic polyps of the lumenal gastrointestinal tract.
  • CNS malformations and neurometabolic disorders
  • Correlation of advanced neuroimaging and normal and abnormal CNS histology
  • Developmental brain abnormalities, particularly in premature infants
  • Discovery and pre-clinical validation of novel genetic lesions in lymphoma and solid tumors
  • Ethical issues in medical malpractice expert witness testimony
  • Exosomal microRNA (miRNA, miR) as a biomarker in neuropsychiatric diseases
  • Histologic features in congenital nevi in children under the age of 2 years old.
  • iCAT Study: Multi-institutional collaboration, profiling pediatric solid tumors.
  • Identification and characterization of novel translocations in pediatric cancers.
  • Indicators of clonal progression in pediatric myelodysplastic syndromes and bone marrow failure.
  • Malignant melanoma in the pediatric age group
  • Mechanisms and therapy of ALK driven cancers, including the development of a specific cancer vaccine
  • Mechanisms of pulmonary injury and maldevelopment
  • Mechanisms that govern the formation of chromosomal translocations in normal and neoplastic cells
  • Molecular genetics of inherited anemias, particularly sideroblastic anemias
  • Molecular genetics of iron metabolism disorders
  • Molecular genetics of pediatric bone marrow failure disorders and myelodysplastic syndromes
  • Molecular genetics of pediatric myelodysplastic syndromes and bone marrow failure disorders.
  • Molecular profiling of pediatric solid tumors and hematologic malignancies
  • Myofiber architecture in congenital heart defects
  • Neuropathology of traumatic brain injury, including chronic traumatic enchepalopathy
  • Papillary thyroid carcinoma in children
  • Pathobiology of congenital myopathies and muscular dystrophies
  • Pathobiology of non-rhabdomyosarcomatous soft tissue tumors
  • Pathobiology of pediatric solid tumors
  • Pathobiology of pediatric tumors and tumor-like lesions
  • Pathobiology of rhabdomyosarcoma
  • Pathologic diagnosis of pediatric metabolic/genetic disorders
  • Pathology of pediatric tumors
  • Pediatric renal pathology: Growth and development
  • Pediatric renal pathology: Immune consequences of T-cell dysfunction
  • Pediatric renal pathology: Metabolic abnormalities
  • Pediatric renal pathology: Whole slide imaging and three-dimensional reconstruction
  • Placental pathology associated with untoward outcome in term pregnancies
  • Postmortem imaging as adjunct to or replacement for autopsy
  • Precision medicine diagnostics and clinical trials of brain tumors
  • Profile Study: Molecular profiling of cancers through the Dana Farber Cancer Institute.
  • Spitz nevus and atypical spitzoid melanocytic proliferations.
  • Trials of neuroprotective agents in CNS hypoxic/ischemic injury
  • Vascular malformations and tumors
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital
300 Longwood Avenue, Boston, MA 02115
For Patients: 617-355-6000
For Referring Providers: 844-BCH-PEDS | 844-224-7337