Research and Innovation

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Innovation At Work

In 2002, Boston Children's doctors performed the world's first serial transverse enteroplasty (STEP) procedure, a surgical technique developed by Tom Jaksic, MD and Heung Bae Kim, MD, which lengthens the bowels of children with short bowel syndrome.

Since its invention, Boston Children's doctors have performed 19 STEP procedures with increasing success, establishing Boston Children's Hospital as one of the preeminent hospitals in the world for the treatment of short bowel syndrome.

Finally, watch and listen to Drs. Kim, Jaksic and Duggan below as they describe the history and benefits of STEP.

How STEP works


Clinical Trials

Copper Status in Infants with Prolonged Dependence on Parenteral Nutrition

Principal Investigator: Danielle Arsenault, FNP-BC

Department: The Division of GI/Nutrition; Center for Advanced Intestinal Rehabilitation (CAIR)

Protocol Status: Open for Recruitment

Trial Description: The purpose of this study is to determine the frequency of copper deficiency in infants on parenteral nutrition (PN), and to correlate these findings with clinical, demographic and nutritional risk factors. Copper is known to play a critical role in many important physiologic processes; however little is know about optimal dosing of this micronutrient in PN-dependent infants. The findings of this study will serve to guide clinical practice regarding provision of the appropriate amount of copper in this patient population.

Study procedures: PN-dependent infants enrolled in this study will undergo laboratory testing and growth assessment every 8 weeks for the duration of PN-dependence or until conclusion of the 1 year study period. Data will also be collected about types and amounts of gastrointestinal losses as well as the parenteral and enteral intake of copper and other specific nutrients.  

Compensation: There is no compensation for participating in this study beyond contribution to the greater knowledge about optimal copper provision in the PN-dependent infant population.

Recruitment Info: Infants less than 1 year of age (adjusted for prematurity) that have been PN-dependent for a minimum of 30 days and will likely continue to be PN-dependent for a minimum of 8 weeks following enrollment will be recruited for this study.

Recruitment Contact Phone: 617-919-3505

Recruitment Contact Email:

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The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO