Brain Tumor Center Research and Innovation

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Research & clinical trials

Our program offers unique access to a range of clinical trials in which your child can receive the newest brain tumor treatments. Through this research, our physicians work to improve current therapeutic approaches and outcomes for many hard-to-treat pediatric brain tumors.

Dana-Farber/Boston Children's Hospital Cancer Center is the only center in New England that offers Phase I Boston Children's Oncology Group clinical trials. We are also a member of the Pediatric Oncology Experimental Therapeutic Investigators Consortium and the Department of Defense Neurofibromatosis Clinical Trials Consortium.

In addition, we are consistently one of the most highly funded pediatric brain tumor research centers in the United States, and rapidly translating scientific discoveries to the bedside is a major focus of the program. Members of our brain tumor team:

  • played a key role in the identification and application of antiangiogenic treatments for pediatric brain tumors

  • launched new studies investigating gene profiling of patients’ tumors and the development of personalized treatment approaches

  • pioneered the development of new treatments for specific highly malignant tumors such as AT/RT (Atypical Teratoid Rhabdoid Tumor)

  • development of new targeted therapies for diffuse intrinsic pontine glioma (DIPG)

  • creation of the only pediatric low-grade astrocytoma research program

  • molecular profiling of pediatric brain tumors for any patient

  • are developing tissue registries to better classify and treat certain types of brain tumors

Survivorship clinic

Both the tumors and their treatments have potential for long-term side effects and complications, including learning disabilities, emotional challenges, personality changes and movement and sensory deficits. After treatment is complete, we offer fully coordinated follow-up care through the Stop & Shop Family Neuro-Oncology Outcomes Clinic to help families and patients find resources to cope with any side effects of treatment.

Clinical Trials

Clinical trials are studies that evaluate the effectiveness of new interventions. There are different types of cancer clinical trials, such as prevention trials, early detection trials, and treatment trials. The Pediatric Brain Tumor Program participates in several multi-center national clinical trials.

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This department is currently not accepting appointment requests online. Please call us at: 617-355-6000. International +1-617-355-6000.

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The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO