Research and Innovation

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The Bone Health Program has been actively involved in exploring the causes and symptoms of pediatric low bone density and researching new and improved treatments. Researchers at Boston Children's Hospital are currently investigating:

  • Obese Subjects with Prader-Willi Syndrome to evaluate total body fat mass and food related behavior:
    A randomized, double-blind placebo-controlled phase 3 trial of ZGN-440 in obese subjects with Prader-Willi Syndrome to evaluate total body fat mass.
  • Sugar Sweetened Beverages and Cardiovascular Disease Risk:
    A randomized, double-blinded trial to compare the effects of three types of beverages on disease risk and body weight.
  • A Novel Diet-Phenotype Interaction Affecting Body Weight:
    How people with different blood insulin levels after consuming carbohydrate respond to different diets for weight loss is compared.
  • Use of Farnesyltransferase inhibitor (FTI) Lonafarnib for Hutchinson-Gilford Progeria Syndrome (HGPS) and progeroid laminopathies: 
    This protocol measures an experimental drug's effect using many tests in hopes that this drug will have therapeutic effect on progeria. 
  • PHACS (PH200) Adolescent Master Protocol (AMP):
    This protocol will look at problems in metabolism such as insulin resistance and diabetes (trouble with blood sugar) and mitochondrial changes that may lead to heart disease. 
  • Acute Lymphoblastic Leukemia (ALL)
  • Defining the Cause of Obesity in Narcolepsy
  • Clinical Study of Spinal Muscular Atrophy
  • Relation of Left Ventricular Mass to Lean Mass and Fat Mass
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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