Bone Health Program | Research and Innovation

 

The Bone Health Program has been actively involved in exploring the causes and symptoms of pediatric low bone density and researching new and improved treatments. Researchers at Boston Children's Hospital are currently investigating:

  • Delayed Puberty: Causes and Consequences, Phenotypes and Genotypes:
    This protocol seeks to elucidate multiple features of delayed puberty.
  • Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer and History of Bone Fracture:
    This study in childhood cancer survivors with history of post-cancer therapy bone fracture will inform the understanding of skeletal fragility assessment.
  • A Multicenter, Observational, Prospective, Natural History Study of Homocystinuria due to Cystathionine Beta-Synthase Deficiency in Pediatric and Adult Patients:
    A research study to find out more about homocystinuria, a disease in which the body is unable to break down some proteins (amino acids) properly.
  • Use of Farnesyltransferase inhibitor (FTI) Lonafarnib for Hutchinson-Gilford Progeria Syndrome (HGPS) and progeroid laminopathies: 
    This protocol measures an experimental drug's effect using many tests in hopes that this drug will have therapeutic effect on progeria. 
  • PHACS (PH200) Adolescent Master Protocol (AMP):
    This protocol will look at problems in metabolism such as insulin resistance and diabetes (trouble with blood sugar) and mitochondrial changes that may lead to heart disease. 
  • The Pathophysiology of Hypothalamic Obesity after Craniopharyngioma
  • AG-348 in Adult Patients with Pyruvate Kinase Deficiency
  • Relation of Left Ventricular Mass to Lean Mass and Fat Mass
  • Clinical Study of Spinal Muscular Atrophy