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The Pediatric Critical Care Nutrition Program at Boston Children's Hospital consists of dieticians, clinical nutrition specialists, pharmacists, nurses and physicians, all working together to advance the nutritional health of children with critical illness.
We conduct clinical trials, evaluate practice standards and examine existing evidence in order to develop the best possible nutrition therapies for your child.
Dr. Mehta is the Principal Investigator of 2 large international studies of nutrient delivery in mechanically ventilated children. The results of the first study have now been published. (Crit Care Med. 2012 Jul;40(7):2204-11)
The 2nd International study of nutrition practice in mechanically ventilated children started on May 11, 2011. We had a large number of returning and new sites this year. Data entry was completed on Jan 31st 2012. Over 60 sites completed data collection with more than 1200 subjects enrolled. The study is now closed for data entry. Data cleaning is complete. Participating pediatric ICUs will soon receive a bench marked, individualized site-report, which will allow comparison of practice at each center with the rest of the international cohort.
The 2nd International study of nutrition practice in mechanically ventilated children started on May 11, 2011. We had a large number of returning and new sites this year. Data entry was completed on Jan 31st 2012. Over 60 sites completed data collection with more than 1200 subjects enrolled.
The study is now closed for data entry and data cleaning is complete. Participating pediatric ICU's received a bench marked, individualized site-report in December 2012 which allowed comparison of practice at each center with the rest of the international cohort. Please review the report and consider ways to disseminate the observations among key stake holders,and identify areas in which your site practice could be further improved. We will be happy to help or suggest ways in which previous sites have utilized these reports. We are extremely grateful for your overwhelming participation and are positive that this collaborative effort will significantly help enhance the quality of bedside nutrition therapy in our PICU's.
Metabolic state after cardiopulmonary bypass in infants following Fontan surgery
Mehta, Costello, Bechard, Laussen, Duggan
This study is aimed at assessing the feasibility of continuous measurements of resting energy expenditure and determining the metabolic profile of infants during the critical early post-operative period.
Mehta, Raphael, Jaksic, Duggan
The aim of this study is to serially measure lean body mass and fat mass changes in children with SBS, using bioelectric impedance, DXA scanning and isotope dilution techniques and to examine the impact of serial energy balance and absorptive function on changes in lean body mass in children with SBS.
Mehta, Hamilton, Leavitt, McAleer, Mitchell, Duggan
This multidisciplinary study was conducted with an aim to describe nutrient intake in critically ill children, to identify risk factors associated with avoidable interruptions to enteral nutrition (EN) and to highlight opportunities to improve enteral nutrient delivery in a busy tertiary pediatric intensive care unit (PICU).
Mehta, Hamilton, McAleer, Kleinman, Duggan
We have designed a multipronged nutritional intervention for physicians and nurses that addresses deficiencies highlighted in Phase 1 study (now completed) - a) time of initiation of EN after PICU admission, b) nutritional assessment and establishing caloric goal for individual patients, c) preventing avoidable interruptions to EN, d) assisting bedside EN delivery using evidence and consensus-based guidelines. We hypothesize that such a multipronged, stepwise approach to systemic deficiencies / barriers to EN delivery in the PICU will decrease PN utilization and costs, decrease CVL utilization, decrease length of PICU stay and potentially impact on the incidence of infectious complications in critically ill children.
Mehta, Bechard, Leavitt, Duggan
Accurate prediction of energy requirements is difficult in children with metabolic instability, and the likelihood of cumulative energy imbalance is high. We have described a model of targeted IC in selected critically ill children who are at high risk of metabolic derangements. We are now examining the bedside impact of such an approach in terms of influencing nutrient intake and its role in avoiding large energy imbalances during the PICU stay.
Bechard, Gordon, Gura, Feldman, Guinan, Duggan
We aim to compare the effects of titrating parenteral nutrition (PN) to measured energy expenditure on body composition, glycemic control, and infectious complications in children undergoing hematopoetic stem cell transplantation. Subjects will be randomized to receive standard PN vs. PN titrated to resting energy expenditure (by indirect calorimetry). We hypothesize that children receiving PN closely matched to energy expenditure will have improved outcomes.
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”