Division of Gastroenterology, Hepatology and Nutrition - Comparison Of Fibroscan And Serum Fibrosis Markers With Histological Evaluation Of Liver Fibrosis In Pediatric Patients Presenting For Liver Biopsy

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Principal Investigator: Maureen Jonas, MD

Department: Gastroenterology, Center for Childhood Liver Disease

Protocol Status: Open for Recruitment

Trial Description: This is research into other ways to detect cirrhosis, or the degree of liver fibrosis. The study uses a combination of special research blood tests and a technology called “transient elastography” to assess the severity of liver scarring.  The elastography is done with a machine called a “FibroScan” (Echosens, Paris, France), that uses ultrasound technology to measure the stiffness of the liver.

The objective of this study is to determine if liver stiffness as measured by elastography correlates to the amount of scarring (fibrosis) seen on the liver biopsy.  If it does, in the future some liver biopsies may be avoided.

Protocol Status:  Open for recruitment

Recruitment Info: The patient must have had a liver biopsy within 1 year of the study.  In addition, subjects may not be pregnant, have ascites (fluid in the abdomen) or a BMI greater than 35.

PI contact: Maureen Jonas, MD, Center for Childhood Liver Disease

PI Phone: 617-355-5837 

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