Resident Research

Christy Ullrich and Anne Wu

Although there is no formal research requirement, many residents do research, particularly clinical research during their training. Children's Hospital and Boston Medical Center both have federally funded General Clinical Research Centers (called the Clinical and Translational Study Unit at Children's), and outstanding Clinical Research Center core services, with biostatisticians, epidemiologists, and other personnel to aid in experimental design. Children's is also part of Harvard Catalyst, a consortium of Harvard hospitals and resources dedicated to clinical research. The Harvard Catalyst provides incredible resources for interconnecting investigators with common interests across the Harvard community and has introduced very powerful tools that facilitate clinical research, such as the Shared Health Research Information Network (SHRINE), an interactive database of patients seen at the Harvard hospitals who meet clinical criteria of interest. Catalyst also provides education and training in clinical research, pilot funding, core facilities and many other services. Faculty members at both Children's and BMC are eager to help residents with research, and many serve as mentors for research projects. The Academic Development Block provides a time to do small projects or conclude larger ones and the new Academy of Investigation and Academy of Clinical Innovation emphasize research. Both the Department of Medicine at Children's Hospital, and the hospital sponsor Research Days where residents and fellows can present their work. In addition, 19 current or recently graduated BCRP houseofficers submitted 21 abstracts of research they did during residency to the Pediatric Academic Societies spring meeting in Boston, MA., April 28-May 1, 2012. Though not all resident research is published, much of it is, and often it is of high quality. Some examples of research done during residency and published during the past 3.5 years follow (resident names are in bold):

2014

  • Batey L, Moon JE, Yu Y, Wu B, Hirschhorn JN, Shen Y, Dauber A. A novel deletion of IGF1 in a patient with idiopathic short stature provides insight Into IGF1 haploinsufficiency. J Clin Endocrinol Metab. 2014;99:E153-9.
  • Biggs C, Dedeoglu F. A81: spectrum of mevalonate kinase deficiency: is colitis more common than we think? Arthritis Rheumatol. 2014;66 Suppl 11:S114.
  • Burke SJ, Lass E, Thistle P, Katumbe L, Jetha A, Schwarz D, Bolotin S, Barker RD, Simor A, Silverman M. Increased incidence of tuberculosis in zimbabwe, in association with food insecurity, and economic collapse: an ecological analysis. PLoS One. 2014;9:e83387.
  • Farias M, Rathod RH. Standardized clinical assessment and management plans: a clinician-led approach to unwarranted practice variation. Virtual Mentor. 2014;16:115-9.
  • Gorrindo P, Peltz A, Ladner TR, Reddy I, Miller BM, Miller RF, Fowler MJ. Medical students as health educators at a student-run free clinic: improving the clinical outcomes of diabetic patients. Acad Med. 2014;89:625-31.
  • Hadland SE, Austin SB, Goodenow CS, Calzo JP. Weight misperception and unhealthy weight control behaviors among sexual minorities in the general adolescent population. J Adolesc Health. 2014;54:296-303.
  • Hadland SE, Baer TE. The Racial and Ethnic Gap in Substance Use Treatment: Implications for U.S. Healthcare Reform. J Adolesc Health. 2014 (epub ahead of print].
  • Hadland SE, Long WE. A systematic review of the medical home for children without special health care needs. Matern Child Health J. 2014;18:891-8.
  • Hancer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem. 2014 Mar 20. [Epub ahead of print]
  • Jain A, Petty EM, Jaber RM, Tackett S, Purkiss J, Fitzgerald J, White C. What is appropriate to post on social media? Ratings from students, faculty members and the public. Med Educ. 2014;48:157-69.
  • Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014;192:2651-8.
  • Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S, Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT. Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus. Hepatology. 2014;59:1250-61.
  • Macrae D, Grieve R, Allen E, Sadique Z, Morris K, Pappachan J, Parslow R, Tasker RC, Elbourne D; CHiP Investigators. A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med. 2014;370:107-18.
  • Riles EM, Jain AV, Fendrick AM. Medication adherence and heart failure. Curr Cardiol Rep. 2014;16:458
  • Schumacher DJ, Frintner MP, Jain A, Cull W. The 2011 ACGME Standards: Impact Reported by Graduating Residents on the Working and Learning Environment. Acad Pediatr. 2014;14:149-54.
  • Simons LE, Moulton EA, Linnman C, Carpino E, Becerra L, Borsook D. The human amygdala and pain: evidence from neuroimaging. Hum Brain Mapp. 2014;35:527-38.
  • Tocco D, Jain AV, Baines H. The pediatrics milestone pilot project: perspectives of current pediatric residents. Acad Pediatr. 2014;14(2 Suppl):S8-9.

2013

  • Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstrale M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 2013;341:275-8.
  • Batey LA, Welt CK, Rohr F, Wessel A, Anastasoaie V, Feldman HA, Guo CY, Rubio-Gozalbo E, Berry G, Gordon CM. Skeletal health in adult patients with classic galactosemia. Osteoporos Int. 2013;24:501-9.
  • Cheston CC, Flickinger TE, Chisolm MS. Social media use in medical education: a systematic review. Acad Med. 2013;88:893-901.
  • Daly KP, Chandler SF, Almond CS, Singh TP, Mah H, Milford E, Matte GS, Bastardi HJ, Mayer JE, Fynn-Thompson F, Blume ED. Antibody depletion for the treatment of crossmatch-
    positive pediatric heart transplant recipients. Pediatr Transplant. 2013;17:661-9.
  • Dauber A, Corcia L, Safer J, Agus MS, Einis S, Steil GM. Closed-loop insulin therapy improves glycemic control in children aged <7 years: a randomized controlled trial. Diabetes Care. 2013; 36:222-7.
  • Farias M, Jenkins K, Lock J, Rathod R, Newburger J, Bates DW, Safran DG, Friedman K, Greenberg J. Standardized Clinical Assessment And Management Plans (SCAMPs) provide a better alternative to clinical practice guidelines. Health Aff (Millwood). 2013;32:911-20.
  • Fiechtner L, Block J, Duncan DT, Gillman MW, Gortmaker SL, Melly SJ, Rifas-Shiman SL, Taveras EM. Proximity to supermarkets associated with higher body mass index among overweight and obese preschool-age children. Prev Med. 2013; 56(3-4):218-21.
  • Fields EL, Bogart LM, Galvan FH, Wagner GJ, Klein DJ, Schuster MA. Association of discrimination-related trauma with sexual risk among HIV-positive African American men who have sex with men. Am J Public Health. 2013; 103:875-80.
  • Fox MP, Thea DM, Sadruddin S, Bari A, Bonawitz R, Hazir T, Bin Nisar Y, Qazi SA; Pneumonia Studies Group. Low rates of treatment failure in children aged 2-59 months treated for severe pneumonia: a multisite pooled analysis. Clin Infect Dis. 2013;56:978-87.
  • Garbern JC, Mummery CL, Lee RT. Model systems for cardiovascular regenerative biology. Cold Spring Harb Perspect Med. 2013; 3:a014019.
  • Hodges HK, Lee PY, Hausmann JS, Teot LA, Sanford EL, Levin KW. Hypercalcemia and miliary sarcoidosis in a 15-year-old boy. Arthritis Rheum. 2013;65:2112..
  • Izadnegahdar R, Cohen AL, Klugman KP, Qazi SA. Childhood pneumonia in developing countries. Lancet Respir Med. 2013;1:574-84.
  • Izadnegahdar R, Fox MP, Jeena P, Qazi SA, Thea DM. Revisiting pneumonia and exposure status in infants born to HIV-infected mothers. Pediatr Infect Dis J. 2014;33:70-2.
  • Johnson L, Radesky J, Zuckerman B. Cross-cultural parenting: reflections on autonomy and interdependence. Pediatrics. 2013;131:631-3.
  • Kaye E, Mack JW. Parent perceptions of the quality of information received about a child's cancer. Pediatr Blood Cancer. 2013;60:1896-901.
  • Kentsis A, Shulman A, Ahmed S, Brennan E, Monuteaux MC, Lee YH, Lipsett S, Paulo JA, Dedeoglu F, Fuhlbrigge R, Bachur R, Bradwin G, Arditi M, Sundel RP, Newburger JW, Steen H, Kim S. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med. 2013;5:210-20.
  • Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology. J Leukoc Biol. 2013;94:585-94.
  • Lim J, Petersen S, Schwarz D, Schwarz R, Maru D. A rights-based approach to indoor air pollution. Health Hum Rights. 2013;15:160-7.
  • Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia. Blood. 2013; 121:2199-212.
  • Nigrovic LE, Cohn KA, Lyons TW, Thompson AD, Hines EM, Welsh EJ, Shah SS. Enteroviral testing and length of hospital stay for children evaluated for lyme meningitis. J Emerg Med. 2013;44:1196-200.
  • Palazuelos D, Ellis K, Im DD, Peckarsky M, Schwarz D, Farmer DB, Dhillon R, Johnson A, Orihuela C, Hackett J, Bazile J, Berman L, Ballard M, Panjabi R, Ternier R, Slavin S, Lee S, Selinsky S, Mitnick CD. 5-SPICE: the application of an original framework for community health worker program design, quality improvement and research agenda setting. Glob Health Action. 2013;6:19658.
  • Platt C, Geha RS, Chou J. Gene hunting in the genomic era: Approaches to diagnostic dilemmas in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2013 [epub ahead of print]
  • Recher M, Karjalainen-Lindsberg ML, Lindlöf M, Söderlund-Venermo M, Lanzi G, Väisänen E, Kumar A, Sadeghi M, Berger CT, Alitalo T, Anttila P, Kolehmainen M, Franssila R, Chen T, Siitonen S, Delmonte OM, Walter JE, Pessach I, Hess C, Simpson MA, Navarini AA, Giliani S, Hedman K, Seppänen M, Notarangelo LD. Genetic variation in schlafen genes in a patient with a recapitulation of the murine Elektra phenotype. J Allergy Clin Immunol. 2013 [epub ahead of print]. 
  • Sanford EL. Pediatrics-anesthesia combined residency training: an applicant's perspective. Anesth Analg. 2013;116:1386-8.
  • Sankaran VG, Agrawal PB. Stimulating erythropoiesis in neonates. Am J Hematol. 2013;88:930-1
  • Sankaran VG, Gallagher PG. Applications of high-throughput DNA sequencing to benign hematology. Blood. 2013;122:3575-82.
  • Sankaran VG, Joshi M, Agrawal A, Schmitz-Abe K, Towne MC, Marinakis N, Markianos K, Berry GT, Agrawal PB. Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus. Blood. 2013;122:3845-7.
  • Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. Curr Opin Genet Dev. 2013;23:339-44.
  • Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med. 2013;3:a011643. 
  • Schaefer EA, Chung RT. HCV and host lipids: an intimate connection. Semin Liver Dis. 2013;33:358-68.

2012

  • Banerji V, Frumm SM, Ross KN, Li LS, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Alexe G, Tolliday N, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, Roti G, Aster JC, Hahn WC, Kung AL, Stegmaier K. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. J Clin Invest. 2012;122:935-47.
  • Cohn KA, Thompson AD, Shah SS, Hines EM, Lyons TW, Welsh EJ, Nigrovic LE. Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Pediatrics. 2012;129:e46-53
  • Crapp S, Harrar D, Strother M, Wushensky C, Pruthi S. Rocky Mountain spotted fever: 'starry sky' appearance with diffusion-weighted imaging in a child. Pediatr Radiol. 2012; 42:499-502.
  • Farias M, Friedman KG, Powell AJ, de Ferranti SD, Marshall AC, Brown DW, Kulik TJ. Dynamic evolution of practice guidelines: analysis of deviations from assessment and management plans. Pediatrics. 2012; 130:93-8.
  • Fields EL, Bogart LM, Smith KC, Malebranche DJ, Ellen J, Schuster MA. HIV risk and perceptions of masculinity among young black men who have sex with men. J Adolesc Health. 2012; 50:296-303.
  • Forester CM, Terry J, Lee EY, Simoneau T, Haver K. Skin lesions and lung cysts in a neonate. J Pediatr. 2012; 160:1061-1.e1.
  • Hadland SE, Marshall BD, Kerr T, Lai C, Montaner JS, Wood E. Ready access to illicit drugs among youth and adult users. Am J Addict. 2012; 21:488-90.
  • Hadland SE, Marshall BD, Kerr T, Qi J, Montaner JS, Wood E, Suicide and history of childhood trauma among street youth. J Affect Disord. 2012; 136:377-80.
  • Hadland SE, Milloy MJ, Kerr T, Zhang R, Guillemi S, Hogg RS, Montaner JS, Wood E. Young age predicts poor antiretroviral adherence and viral load suppression among injection drug users. AIDS Patient Care STDS. 2012; 26:274-80.
  • Hadland SE, Werb D, Kerr T, Fu E, Wang H, Montaner JS, Wood E. Childhood sexual abuse and risk for initiating injection drug use: a prospective cohort study. Prev Med. 2012; 55:500-4.
  • Henrickson S, Altshuler D. Risk and return for the clinician-investigator. Sci Transl Med. 2012; 4:135cm6.
  • Henrickson SE, Agyemang AF, Garg S, Hafler JP. Integrating clinical perspectives into graduate education. Clin Immunol. 2011; 141:228-30.
  • Leung DT, Bogetz J, Itoh M, Ganapathi L, Pietroni MA, Ryan ET, Chisti MJ. Factors associated with encephalopathy in patients with salmonella enterica serotype typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh. Am J Trop Med Hyg. 2012; 86:698-702.
  • Lyons TW, McAdam AJ, Cohn KA, Monuteaux MC, Nigrovic LE. Impact of in-hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis. J Hosp Med. 2012; 7:517-20.
  • Michelson KA, Monuteaux MC, Stack AM, Bachur RG. Pediatric emergency department crowding is associated with a lower likelihood of hospital admission. Acad Emerg Med. 2012; 19:816-20.
  • Musallam KM, Sankaran VG, Cappellini MD, Duca L, Nathan DG, Taher AT. Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia. Blood. 2012; 119:364-7.
  • Sankaran VG, Sapp MV. Persistence of fetal hemoglobin expression in an older child with trisomy 13. J Pediatr. 2012; 160:352.
  • Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio J, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012; 122:2439-43.
  • Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev. 2012; 26:2075-87.
  • Sankaran VG, Sapp MV. Persistence of fetal hemoglobin expression in an older child with trisomy 13. J Pediatr. 2012; 160:352.
  • Zhang L, Sankaran VG, Lodish HF. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyteerythroid progenitor lineage commitment. Leukemia. 2012; 26:2310-6.

2011

  • Ajjampur SS, Koshy B, Venkataramani M, Sarkar R, Joseph AA, Jacob KS, Ward H, Kang G. Effect of cryptosporidial and giardial diarrhoea on social maturity, intelligence and physical growth in children in a semi-urban slum in south India. Ann Trop Paediatr. 2011; 31:205-12.
  • Farias M, Ziniel S, Rathod RH, Friedman KG, Colan S, Newburger JW, Fulton DR. Provider attitudes toward Standardized Clinical Assessment and Management Plans (SCAMPs). Congenit Heart Dis. 2011; 6:558-65
  • Fornwalt BK. The dys-synchrony in predicting response to cardiac resynchronization therapy: a call for change. J Am Soc Echocardiogr. 2011; 24:180-4.
  • Friedman KG, Kane DA, Rathod RH, Renaud AM, Farias M, Geggel R, Fulton DR, Lock JE, Saleeb SF. Pediatric chest pain: Reducing resource utilization using a standardized clinical assessment and management plan. Pediatrics. 2011; 128:239-45.
  • Geva A, Brigger MT. Dexamethasone and tonsillectomy bleeding: A meta-analysis. Otolaryng Head Neck. 2011; 144:838-43.
  • Hadland SE, Marshall BD, Kerr T, Zhang R, Montaner JS, Wood E. A comparison of drug use and risk behavior profiles among younger and older street youth. Subst Use Misuse. 2011; 46:1486-94.
  • Hadland SE, Marshall BD, Kerr T, Qi J, Montaner JS, Wood E. Depressive symptoms and patterns of drug use among street youth. J Adolesc Health. 2011; 48:585-90.
  • Johnson, L. Gould, L. Dunn, J. Berkelman, R. Mahon, B. Salmonella infections associated with international travel: A foodborne diseases active surveillance network (FoodNet) study. Foodborne Pathog Dis. 2011; 8:1031-7.
  • Loddenkemper T, Fernández IS, Peters JM. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011; 28:154-64.
  • Numis AL, Major P, Montenegro MA, Muzykewicz DA, Pulsifer MB, Thiele EA. Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex. Neurology. 2011; 76:981-7.
  • Peacock-Villada E, Richardson BA, John-Stewart GC. Post-HAART outcomes in pediatric populations: Comparison of resource-limited and developed countries. Pediatrics. 2011; 127:e423-41.
  • Sankaran VG, Menne J, Heller R. Heterozygous disruption of human SOX6 is insufficient to impair erythropoiesis or silencing of fetal hemoglobin. Blood. 2011; 117:4396-7.
  • Sankaran VG, Menne TF, Scepanovic D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci USA. 2011; 108:1519-1524.
  • Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. Fine mapping of unique β-globin locus deletions identifies a functional element necessary for fetal hemoglobin silencing. N Engl J Med, 2011; 365:807-14.
  • van Eeghen AM, Numis AL, Staley BA, Therrien SE, Thibert RL, Thiele EA. Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review. Epilepsy Behav. 2011; 20:68-74.
  • Walsh CO, Ziniel SI, Delichatsios HK, Ludwig DS. Nutrition attitudes and knowledge in medical students after completion of an integrated nutrition curriculum compared to a dedicated nutrition curriculum: a quasi-experimental study. BMC Med Educ. 2011; 11:58.
  • Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011; 334:993-6.
  • Oshrine B, Lehmann LE, Duncan CN. Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. J Pediatr Hematol Oncol. 2011; 33:e92-7.
  • Ozcan E, Rauter I, Garibyan L, Dillon SR, Geha RS. Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J Allergy Clin Immunol. 2011; 128:601-9.
  • Tuysuzoglu S, Corliss HL, Fitzgerald SM, Abascal BR, Samples CL. Acceptability and feasibility of rapid HIV testing in an adolescent clinic setting: Youth testing attitudes, know-ledge, and behaviors. J Adol Health. 2011; 49:609-14.