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| Christy Ullrich and Anne Wu working on their reticulocyte hemoglobin project |
Although there is no formal research requirement, many residents do research, particularly clinical research during their training. Children's Hospital has a federally funded General Clinical Research Center (called the Clinical and Translational Study Unit at Children's), and outstanding Clinical Research Program Core Services, with biostatisticians, epidemiologists, and other personnel to aid in experimental design. Children's is also part of Harvard Catalyst, a consortium of Harvard hospitals and resources dedicated to clinical research. Faculty members at both Children's and BMC are eager to help residents with research, and many serve as mentors for research projects. The Academic Development Block provides a time to do small projects or conclude larger ones. Both the Department of Medicine at Children's Hospital, and the hospital sponsor Research Days where residents and fellows can present their work. In addition, 21 current or recently graduated BCRP houseofficers submitted 24 abstracts of research they did during residency to the Pediatric Academic Societies spring meeting in Vancouver, BC, May 1-4, 2010. Though not all resident research is published, much of it is, and often it is of high quality. Some examples of research done during residency and published during the past 3.5 years follow (resident names are in bold):
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- Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. Fine mapping of unique β-globin locus deletions identifies a functional element necessary for fetal hemoglobin silencing. N Engl J Med, in press.
- Fornwalt BK. The dys-synchrony in predicting response to cardiac resynchronization therapy: a call for change. J Am Soc Echocardiogr. 2011; 24:180-4.
- Friedman KG, Kane DA, Rathod RH, Renaud AM, Farias M, Geggel R, Fulton DR, Lock JE, Saleeb SF. Pediatric chest pain: Reducing resource utilization using a standardized clinical assessment and management plan. Pediatrics. 2011; In press.
- Geva A, Brigger MT. Dexamethasone and tonsillectomy bleeding: A meta-analysis. Otolaryng Head Neck. 2011; 144:838-43.
- Gray J, Davis D, Smallcomb J, Pursley D, Geva A, Chawla N. Network analysis of team structure in the neonatal intensive care unit. Pediatrics. 2010; 125:e1460-7.
- Hadland SE, Marshall BD, Kerr T, Zhang R, Montaner JS, Wood E. A Comparison of Drug Use and Risk Behavior Profiles Among Younger and Older Street Youth. Subst Use Misuse. 2011 Mar 21. [Epub ahead of print].
- Hadland SE, Marshall BD, Kerr T, Qi J, Montaner JS, Wood E. Depressive symptoms and patterns of drug use among street youth. J Adolesc Health. 2011; 48:585-90.
- Johnson, L. Gould, L. Dunn, J. Berkelman, R. Mahon, B. Salmonella infections associated with international travel: A foodborne diseases active surveillance network (FoodNet) study. Foodborne Pathogens and Disease. 2011; In press.
- Koegel LK, Koegel RL, Green-Hopkins I, Barnes CC. Brief report: Question-asking and collateral language acquisition in children with autism. Journal of Autism and Developmental Disorders. 2010; 40:509-15.
- Loddenkemper T, Fernández IS, Peters JM. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011; 28:154-64.
- Numis AL, Major P, Montenegro MA, Muzykewicz DA, Pulsifer MB, Thiele EA. Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex. Neurology. 2011; 76:981-7.
- Peacock-Villada E, Richardson BA, John-Stewart GC. Post-HAART outcomes in pediatric populations: Comparison of resource-limited and developed countries. Pediatrics. 2011; 127:e423-41.
- Sankaran VG, Menne J, Heller R. Heterozygous disruption of human SOX6 is insufficient to impair erythropoiesis or silencing of fetal hemoglobin. Blood. 2011; 117:4396-7.
- Sankaran VG, Menne TF, Scepanovic D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci USA. 2011; 108:1519-1524.
- Sankaran VG, Nathan DG. Reversing the hemoglobin switch. N Engl J Med. 2010; 363: 2258-60.
- Shin C, Nam JW, Farh KK, Chiang HR, Shkumatava A, Bartel DP. Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell. 2010; 38:789-802.
- Tuysuzoglu S, Corliss HL, Fitzgerald SM, Abascal BR, Samples CL. Acceptability and feasibility of rapid HIV testing in an adolescent clinic setting: Youth testing attitudes, know-ledge, and behaviors. J Adol Health. 2011; In press.
- van Eeghen AM, Numis AL, Staley BA, Therrien SE, Thibert RL, Thiele EA. Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review. Epilepsy Behav. 2011; 20:68-74.
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- Chan GJ, Parco K, Sihombing M, Tredwell S, O'Rourke E. Improving health services to displaced persons in Aceh, Indonesia: A Balanced Scorecard. Bull World Health Org. 2010; 88:709-12.
- Chung EY, Huang L, Schneider L. Safety of influenza vaccine administration in egg-allergic patients. Pediatrics 2010; 125: e1024-e1030.
- Depositario-Cabacar DT, Peters JM, Pong AW, Roth J, Rotenberg A, Riviello JJ Jr, Takeoka M. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010; 51:1319-22
- Friedman KG, Rathod RH, Farias M, Graham D, Atwood S, Powell A, Fulton D, Newburger JW, Colan S, Jenkins K, Lock JE. Evaluation of resource utilization after introduction of a standardized clinical assessment and management plan." Congenit Heart Dis 2010; 5:374-81.
- Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet. 2010; 42:1049-51.
- Hadland SE, Kerr T, Marshall BD, Small W, Lai C, Montaner JS, Wood E. Non-injection drug use patterns and history of injection among street youth. Eur Addict Res. 2010; 16:91-8.
- Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high accuracy mass spectrometry. Ann Emerg Med. 2010; 55:62-70.
- Kesselheim JC, Johnson J, Joffe S. Ethics consultation in children's hospitals: results from a survey of pediatric clinical ethicists. Pediatrics. 2010; 125:742-6.
- Marma AK, Berry JD, Ning H, Persell SD, Lloyd-Jones DM. The distribution of 10-year and lifetime predicted risks for cardiovascular disease among United States adults: findings from the National Health and Nutrition Examination Survey 2003-2006. Circulation: Cardiovascular Quality & Outcomes. 2010; 3:8-14.
- Maru, D, Schwarz, R. Andrews, J., Basu, S., Sharma A., Moore, C. Turning a Blind Eye: the mobilization of radiology services in resource-poor regions. Globalization and Health. 2010; 6:18
- Oshrine B, Lehmann LE, Duncan CN. Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. J Pediatr Hematol Oncol. 2011; 33:e92-7.
- Pier DB, Hallbergson A, Peters JM. Guillain-Barré syndrome in a child with pain: lessons learned from a late diagnosis. Acta Paediatr. 2010; 99:1589-91.
- Rakoff-Nahoum S, Bousvaros A. Innate and adaptive immune connections in inflammatory bowel diseases. Curr Opin Gastroenterol. 2010; 26:572-7.
- Rathod RH, Farias M, Friedman KG, Graham D, Fulton D, Newburger JW, Colan S, Jenkins K, Lock JE. A novel approach to gathering and acting on relevant clinical Information: SCAMPs. Congenit Heart Dis. 2010; 5:343-53.
- Rudloe TF, Harper MB, Prabhu SP, Rahbar R, Vanderveen D, Kimia AA. Acute periorbital infections: who needs emergent imaging? Pediatrics. 2010; 125:e719-26.
- Stein R, Silverstein M. Potential implications of US healthcare reform for American children. Archives of Disease in Childhood 95(8):578-579, 2010.
- Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010; 24: 783-98.
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- Skotko, B. Fasten Your Seatbelt: A Crash Course on Down Syndrome for Brothers and Sisters. Bethesda, MD: Woodbine House, 2009 (Book).
- Demirjian A, Levy O. Safety and efficacy of neonatal vaccination. Eur J Immunol. 2009; 39:36-46.
- Gordon MB, Osganian SK, Emans SJ, Lovejoy FH Jr. Gender differences in research grant applications for pediatric residents. Pediatrics. 2009 124: e355-61.
- Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur R, Steen H. Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics. 2009; 3:1052-61.2
- Kesselheim JC, Lehmann LE, Styron NF, Joffe S. Is blood thicker than water?: ethics of hematopoietic stem cell donation by biological siblings of adopted children. Arch Pediatr Adolesc Med. 2009; 163:413-6.
- Maru, D, Sharma, A, Andrews, J, Basu, S, Thapa, J, Oza, , Bashyal, C, Acharya, B, Schwarz, R. Global health delivery 2.0: using open-access technologies for transparency and operations reseach. PLoS Med. 2009; 6:e1000158.
- O'Donnell KA, Ewald MB. Huffing and puffing to lose weight. Pediatr Emerg Care. 2009; 25:605-7.
- Permaul P, Stutius LM, Sheehan WJ, Rangsithienchai P, Walter JE, Twarog FJ, Young MC, Scott JE, Schneider LC, Phipatanakul W. Sesame allergy: role of specific IgE and skin-prick testing in predicting food challenge results. Allergy Asthma Proc. 2009; 30:643-8.
- Shapiro KA, Caramazza A. Morphological processes in language production. In: Gazzaniga M, editor. The Cognitive Neurosciences, 4th ed. Cambridge, MA, USA: Cambridge University Press; 2009.
- Skotko BG, Capone GT, Kishnani PS. Down Syndrome Diagnosis Study Group. Postnatal diagnosis of Down syndrome: synthesis of the evidence on how best to deliver the news. Pediatrics. 2009; 124:e751-8.
- Skotko BG, Kishnani PS, Capone GT. Down Syndrome Diagnosis Study Group. Prenatal diagnosis of Down syndrome: how best to deliver the news. Am J Med Genet A. 2009; 149A:2361-7.
- Smith-Rohrberg Maru D, Bruce RD, Springer SA, Walton M, Altice FL. 2009. Persistence of Virological Benefits Following Directly Administered Antiretroviral Therapy among Drug Users: Results from a Prospective, Randomized Controlled Trial. JAIDS. 50:176-81.
- Wolff M, Bachur R. Serious bacterial infection in recently immunized young febrile infants. Acad Emerg Med. 2009; 16:1284-9.
- Wood JN, Christian CW, Adams CM, Rubin DM. Skeletal surveys in infants with isolated skull fractures. Pediatrics. 2009; 123:e247-52.
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- Bernstein, AS. Sustaining Life: How Human Health Depends on Biodiversity. Oxford Press, 2008 (Book).
- Bernstein AS, Ludwig DS. The importance of biodiversity to medicine. JAMA. 2008; 300:2297-2299.
- Dauber A, Weiss S, Maniaci V, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants after recent immunization. Pediatrics. 2008; 122:e1119-1122.
- Demirjian A, Levy O. Neonatal vaccination: a once in a lifetime opportunity. Pediatr Infect Dis J. 2009; 28:833-5.
- Jolley M, Stinstra J, Pieper S, MacLeod R, Brooks DH, Cecchin F, Triedman JK. A computer modeling tool for comparing novel ICD electrode orientations in children and adults. Heart Rhythm. 2008; 5:565-572.
- Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detection of serious bacterial infections. Pediatrics. 2008; 122:701-10.
- Nelson BD, Herlihy J, Burke TF. A proposal for fellowship training in pediatric global health. Pediatrics. 2008; 121:1261-1262.
- Nelson BD, Lee ACC, Newby PK, Chamberlin MR, Huang C-C. Global health training in pediatric residency programs. Pediatrics. 2008; 122:28-33.
- Permar SR, Kang HH, Carville A, Mansfield KG, Gelman RS, Rao SS, Whitney JB, Letvin NL. Potent simian immunodefici-ency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008; 181:3643-50.
- Solon O, Riddell TJ, Quimbo SA, Butrick E, Aylward GP, Bacate ML, Peabody JW. Associations be-tween cognitive function, blood lead concentration, and nutrition among children in the central Philippines. J Pediat. 2008; 152:237-243.
- Tang MH, Hill KS, Boudreau AA, Yucel RM, Perrin JM, Kuhlthau KA. Medicaid managed care and the unmet need for mental health care among children with special health care needs. Health Serv Res 2008; 43:882-900.
- Wolf CM, Arad M, Ahmad F, Sanbe A, Bernstein SA, Toka O, Konno T, Morley G, Robbins J, Seidman JG, Seidman CE, Berul CI. Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008; 117:144-154
- Wolf CM, Wang L, Alcalai R, Pizard A, Burgon PG, Ahmad F, Sherwood M, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Conner DA, Berul CI, Seidman CE, Seidman JG. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol. 2008; 44:293-303.
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