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| Christy Ullrich and Anne Wu working on their reticulocyte hemoglobin project |
Although there is no formal research requirement, many residents do research, particularly clinical research during their training. Children's Hospital has a federally funded General Clinical Research Center (GCRC), and outstanding Clinical Research Program Core Services, with biostatisticians, epidemiologists, and other personnel to aid in experimental design. Faculty members are also eager to help and many serve as mentors for research projects. The Career Development Block provides a time to do small projects or conclude larger ones. Both the Department of Medicine at Children's Hospital, and the hospital sponsor Research Days where residents and fellows can present their work. Though not all resident research is published, much of it is, and often it is of high quality. Some examples from the past 5 years follow (resident names are in bold):
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- Bernstein, AS. Sustaining Life: How Human Health Depends on Biodiversity. Oxford Press, 2008 (Book).
- Skoto, B. Fasten Your Seatbelt: A Crash Course on Down Syndrome for Brothers and Sisters. Bethesda, MD: Woodbine House, 2009 (Book).
- Bernstein AS, Ludwig DS. The importance of biodiversity to medicine. JAMA. 2008; 300:2297-2299.
- Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur R, Steen H. Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics, in press.
- Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high accuracy mass spectrometry. Ann Emerg Med, in press.
- Demirjian A, Levy O. Safety and efficacy of neonatal vaccination. Eur J Immunol. 2009; 39:36-46.
- Tang MH, Hill KS, Boudreau AA, Yucel RM, Perrin JM, Kuhlthau KA. Medicaid managed care and the unmet need for mental health care among children with special health care needs. Health Serv Res 2008; 43:882-900.
- Nelson BD, Lee ACC, Newby PK, Chamberlin MR, Huang C-C. Global health training in pediatric residency programs. Pediatrics. 2008; 122:28-33.
- Nelson BD, Herlihy J, Burke TF. A proposal for fellowship training in pediatric global health. Pediatrics. 2008; 121:1261-1262.
- Wolf CM, Wang L, Alcalai R, Pizard A, Burgon PG, Ahmad F, Sherwood M, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Conner DA, Berul CI, Seidman CE, Seidman JG. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol. 2008; 44:293-303.
- Wolf CM, Arad M, Ahmad F, Sanbe A, Bernstein SA, Toka O, Konno T, Morley G, Robbins J, Seidman JG, Seidman CE, Berul CI. Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008; 117:144-154
- Jolley M, Stinstra J, Pieper S, MacLeod R, Brooks DH, Cecchin F, Triedman JK. A computer modeling tool for comparing novel ICD electrode orientations in children and adults. Heart Rhythm. 2008; 5:565-72.
- Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants after recent immunization. Pediatrics. 2008; 122:e1119-1122.
- Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detection of serious bacterial infections. Pediatrics. 2008; 122:701-10.
- Robinson JD, Melman Y, Walsh EP. Cardiac conduction disturbances and ventricular tachycardia after prolonged propofol infusion in an infant. Pacing Clin Electrophys. 2008; 31:1070-1073.
- Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008; 121:e879-884.
- Solon O, Riddell TJ, Quimbo SA, Butrick E, Aylward GP, Bacate ML, Peabody JW. Associations be-tween cognitive function, blood lead concentration, and nutrition among children in the central Philippines. J Pediat. 2008; 152:237-243.
- Murphy CG, Glickman JN, Tomczak K, Wang YY, Beggs AH, Shannon MW, Horwitz BH. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene ex-pression. Mucosal Immunol. 2008; 1:297-308.
- Woolf AD, Hussain J, McCullough L, Petranovic M, Chomchai C. Infantile lead poisoning from an Asian tongue powder: A case report & subsequent public health inquiry. Clin Toxicol (Phila). 2008; 46:841-844.
- Stanton B, Huang CC, Armstrong RW, Sectish TC, Palfrey J, Nelson BD, Herlihy JM, Alden E, Keenan W, Szilagyi P. Global health training for pediatric residents. Pediat Ann. 2008; 37:786-7, 792-796.
- Kenyon C, Sandel M, Silverstein M, Shakir A, Zuckerman B. Revisiting the social history for child health. Pediatrics. 2007; 120:e734-738
- Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 2007; 129:1365-1376.
- Conway PH, Edwards S, Stucky ER, Chiang VW, Ottolini MC, Landrigan CP. Variations in management of common inpatient pediatric illnesses: hospitalists and community pediatricians. Pediatrics. 2007; 118:441-447.
- Permar SR, Rao SS, Sun Y, Buzby AP, Kang HH, Letvin NL. Clinical measles after measles virus challenge in SIV-infected, measles virus-vaccinated rhesus monkeys. J Infect Dis. 2007; 196:1784-93.
- Sun Y, Permar S, Buzby AP, Letvin NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol. 2007; 81:8009-8015.
- Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007; 49:137-143.
- Tubman VN, Levine JE, Campagna DR, Monahan-Earley R, Dvorak AM, Neufeld EJ, Fleming MD. X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation. Blood. 2007; 109:3297-3299.
- Shin AY, Almond CS,Mannix RC, Duncan CN, Son MB, McLauchlan HM, Kanaan UB, Litzow JM, Riney PS, Trenor CC 3rd, Fortescue EB, Vinci RJ, Greenes DS, Boston Combined Residency Program. The Boston Marathon Study: a novel approach to research during residency. Pediatrics 2006; 117:1818-1822.
- George RE, Li S, Medeiros-Nancarrow C, Neuberg D, Marcus K, Shamberger RC, Pulsipher M, Grupp SA, Diller L. High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update. J Clin Oncol. 2006; 24:2891-6
- Fox RA, Neufeld EJ, Bennett CM. Rituximab for adolescents with hemophilia and high titre inhibitors. Haemophilia 2006; 12:218-222.
- Ullrich C, Wu A, Armsby C, Rieber S, Wingerter S, Brugnara C, Shapiro D, Bernstein H. Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA 2005; 294: 924-30. (pdf)
- Almond CS, Shin AY, Fortescue EB, Mannix RC, Wypij D, Binstadt BA, Duncan CN, Olson DP, Salerno AE, Newburger JW, Greenes DS. Hyponatremia among runners in the Boston Marathon. N Engl J Med 2005; 352: 1550-1556. (pdf)
- George RE, London WB, Cohn SL, Maris JM, Kretschmar C, Diller L, Brodeur GM, Castleberry RP, Look AT. Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 Months old with disseminated neuroblastoma: A Pediatric Oncology Group study. J Clin Oncol 2005; 23:6466-6473.
- Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA. Effect of reducing interns' work hours on serious medical errors in intensive care units. N Engl J Med 2004; 351:1838-1848.
- George RE, Lipschultz SE, Lipsitz SR, Colan SD, Diller L. Association between congenital cardiovascular malformations and neuroblastoma. J Pediatr 2004; 144:444-448.
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