Children's Hospital Boston  300 Longwood Avenue
Boston, MA 02115
(617) 355-6000
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My Child Has:
Allergy Immunotherapy
An allergy is an abnormal reaction or increased sensitivity to certain substances in the environment. The substances that cause this sensitivity or reaction are called allergens.

What is allergy immunotherapy?

The purpose allergy immunotherapy, or allergy shots, is to increase resistance to specific allergens by injecting small doses of each allergen into the upper arms, at intervals, over a prolonged period of time. Usually, this will cause the allergic symptoms to decrease or disappear completely.

How often are allergy shots administered?

The first injections are very dilute and are given at weekly intervals.The concentration of the allergen is then increased gradually, over a period of approximately 20 weeks until a maintenance dosage is reached. Maintenance dosage is given less frequently, on an every two to four week schedule.

Will there be a reaction?
An allergic reaction can occur at any time during the course of treatment. A reaction can occur within the first 30 minutes following an injection, or it may be delayed for up to 12-24 hours. Most reactions are local, such as itching, pain and swelling at the injection site. It is important not to rub or scratch this site; a cold compress may help to lessen these side effects.

Occasionally, more severe or systemic reactions (such as hives or shock) may occur. The most severe reactions usually occur within the first 30 minutes after an injection; any reactions occurring after that time are generally mild. For this reason, you must remain under observation in the waiting room for 30 minutes after your injections. Report any unusual discomfort, itching, hives or other problems immediately to an Allergy Program doctor or nurse. Antihistamines or epinephrine treatment may be needed if symptoms progress. Rarely, more intensive treatment may be necessary.

Is there anything else I should report to the allergist?

The safety and effectiveness of your individualized allergy injection treatment depends on noting and reporting reactions.

Inform your doctor and nurse of any changes in your medical condition, such as wheezing, a cold, a new illness or a pregnancy.

Report any changes in medications. Certain medications, called beta blockers and mao inhibitors, are not to be taken by our patients who receive allergy injections. These medications may increase the serious side effects of allergy therapy. Some of the medications which should not be taken with immunotherapy include beta blockers such as:

  • Propanolol (Indural)
  • Atenolol (Tenormin)
  • Timolol eye drops (Timoptic)
  • Acebutolol (Sectral)
and mao inhibitors such as:
  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)

    Please inform your doctor or nurse if you are taking any of the above medications or if you are taking any other new medications.

    It is important to remain on schedule. If injections are interrupted for a prolonged period of time, we should be contacted before resuming injections.

    Please note: These injections must be given in a medical office with a physician present.

    This information is general. Your physician will discuss your specific course of therapy, its expectations and methods of evaluating the results.

    Remember that injection therapy is only one part of your allergy treatment plan. Environmental controls and medications prescribed by your doctor, combined with injection therapy, are necessary for the successful management of your allergic symptoms.

Additional tips
  • You will initially have a weekly schedule of visits, which will decrease to monthly visits.
  • Wear loose-fitting shirt sleeves to these visits.
  • Wait in the waiting room for 30 minutes after injections.
  • Do not rub injection sites.
  • Report unusual or serious reactions immediately.
  • Report minor reactions before your next injections.
  • Antihistamines and ice should be available at home for delayed reactions.
  • Avoid exposure to allergens and take prescribed medications.
  • Allergy injections are not given when you/your child are acutely ill. If you/your child has a cough, cold, fever or is wheezing, please call before coming in for injections.
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Programs that treat this condition:
Allergy Program
Community Asthma Initiative
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 X The information on this website should not be taken as medical advice,
which can only be given to you by your personal health care professional.
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