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Boston, MA 02115
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My Child Has:
Ventriculomegaly
Programs that treat this condition
 Fetal-Neonatal Neurology Program    Advanced Fetal Care Center  
Ventriculomegaly is a condition in which the ventricular system of the brain is enlarged. The ventricular system contains sac-like pockets called ventricles that are filled with cerebrospinal fluid (CSF).

In the brain of a healthy fetus, the lateral ventricles of the brain are less than 10 mm wide. In the case of a fetus with ventriculomegaly, the lateral ventricles are between 10 mm and 15 mm wide; if they are even larger, the case is considered severe.

In most cases, ventriculomegaly is an isolated condition, so it is not linked to other health problems. However, a small portion of infants afflicted with ventriculomegaly have other health conditions, as well.

Severe cases of ventriculomegaly may result from hydrocephalus (water on the brain), in which CSF builds up and puts pressure on the brain.

What causes ventriculomegaly?
There are three main causes of ventriculomegaly:
  • Impaired absorption of CSF (so the amount of CSF builds up and causes hydrocephalus)
  • Improper brain development
  • Destroyed brain tissue All three of these factors can increase the size of the ventricles in the brain.
Who is affected by ventriculomegaly?
Ventriculomegaly affects about one in 1,000 live births. In some cases, an abnormal gene causes the condition. Ventriculomegaly caused by an abnormal gene may indicate more serious disorders, since chromosome (gene) abnormalities can produce multiple health conditions. However, ventriculomegaly usually occurs spontaneously, not by anything that the mother has done.
How is ventriculomegaly diagnosed?
Prenatal: Ventriculomegaly can be diagnosed before birth by a prenatal ultrasound, a diagnostic imaging technique which uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs. Ultrasounds are used to view internal organs as they function, and to assess blood flow through various vessels.

Ventriculomegaly is detectable via fetal ultrasound by the second trimester. If your doctor suspects that your baby may have ventriculomegaly, an MRI of the fetal brain may also be recommended.

After birth: Diagnostic testing can identify ventriculomegaly at birth, as well. During the examination, the physician obtains a complete prenatal and birth history of the child. If there is a family history of ventriculomegaly, the physician can conduct a chromosomal analysis, either before or after birth, to test for those chromosome problems that cause ventriculomegaly.

How is ventriculomegaly treated?
Ventriculomegaly only needs to be treated if there is hydrocephalus, when CSF builds up in the brain due to a blockage or lack of absorption of CSF. However, any case of ventriculomegaly requires regular pre-natal and post-natal examinations so that physicians can monitor the condition. Once the infant is born, physicians will conduct a physical exam and measure the circumference of the head to ensure that the baby is healthy.
What is the prognosis for ventriculomegaly?
The vast majority of ventriculomegaly cases resolve themselves and the child has a completely normal and healthy development, without any neurological problems. In about one third of the cases, the ventricles shrink, and in about 60 percent of cases, they stay the same size, but do not cause any harm. If the condition is isolated (not linked to any other health conditions or chromosomal abnormalities), the long-term outlook for a child born with mild or moderate ventriculomegaly is excellent.
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