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300 Longwood Avenue
Boston, MA 02115
(617) 355-6000
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My Child Has:
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Ureterocele
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A ureterocele is a ballooning of the ureter at the level of the bladder (intravesical ureter). See Urinary Tract Anatomy. Ureteroceles can occur in patients with single or double ureters. Large ureteroceles may protrude into the urethra causing obstruction. Due to their distortion of the bladder, they can also cause vesicoureteral reflux.
Most ureteroceles are associated with a duplex system (two ureters draining the kidney). Often there is little or no function to the upper segment of kidney. Fortunately this upper segment represents a very small portion of the overall kidney. Histologic or pathologic analysis of these upper pole segments usually demonstrates varying degrees of renal dysfunction which may be one justification for removal of these segments. The most common reason for their removal is the combination of non-function and obstruction.
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Ureteroceles can also be associated with a single collecting system (single ureter draining the kidney). In most cases, there is little or no damage to the kidney. Historically, this condition was identified in adult patients undergoing a urologic evaluation for an unrelated cause. However, with the advent of antenatal ultrasonography during pregnancy, this condition is now seen earlier in life.
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The cause of ureteroceles is unknown, however, some cases have been reported in siblings, suggesting a genetic component. Ureteroceles are more common in females by a ratio of 4:1. Most ureteroceles occur in the Caucasian population. Eighty percent of ureteroceles (80 %) are associated with duplicated collecting system and arise from the upper pole segment. Ten percent occur bilaterally. Single system ureteroceles are often referred to as simple ureteroceles.
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Although doctors can and often do detect ureteroceles during prental ultrasounds, they may not show up until a child is referred to a pediatric urologic specialist because of urinary tract infections. Other symptoms can include an abdominal mass or with a mass at the urethra. This mass is the result of a large ureterocele that is protruding through the openning of urethra. Given the location of the mass with relation to the surrounding structures, a pediatric urologist can usually distinguish this mass from other intralabial lesions such as rhabdomyosarcoma, urethral prolapse, hydrometrocolpus, and periurethral cyst. The prolapsed ureterocele is not a common presentation.
Ureteroceles can cause significant anatomic distortion to other surrounding structures such as the ureteral orifice of the other kidney (contralateral), the trigone and the bladder neck. This may result in contralateral vesicoureteral reflux due to distortion of the bladder or cause contralateral reflux due to obstruction by the ureterocele at the bladder neck. Certain types of ureteroceles such as the cecoureterocele (a ureterocele that extends beyond the bladder sphincter) can cause incontinence (wetting) by interference with the normal continence mechanism due to the submucosal extension of the ureterocele sac. Less frequent presentations of ureterocele include hematuria, failure to thrive, abdominal pain, or pelvic pain.
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Ultrasonography is the first imaging test used in evaluation of an infant with a urinary tract infection or as postnatal follow-up to known prenatal hydronephrosis. A renal ultrasound is a non-invasive test in which a transducer is passed over the kidney producing sound waves which bounce off the kidney, transmitting a picture of the organ on a video screen. The test is used to determine the size and shape of the kidney, and to detect a mass, kidney stone, cyst, or other obstruction or abnormalities. The kidneys, ureters, and bladder should all be surveyed.
In infants and children, the normal ureter is not visualized by ultrasound. The identification of a ureter by ultrasound indicates an abnormal finding necessitating full evaluation. Dilatation of the ureter is usually secondary to reflux or obstruction. Among patients with ureteroceles involving a duplex system (two ureters draining one kidney), the renal ultrasound usually shows a dilated upper pole segment with little renal cortex. On occasion, there may be near normal appearing renal cortex associated with the dilated upper pole segment. In single system ureteroceles, the kidneys often appear normal or may demonstrate mild hydronephrosis. In our experience, abnormalities of the renal echotexture are unusual with single system ureteroceles.
Identification of the ureterocele during the bladder ultrasound can be challenging. If the bladder is empty, the ureterocele wall may be touching the bladder wall making the distinction between the two impossible. In this instance, the entire ureterocele may be mistaken for the bladder. Trained pediatric radiologists aware of this phenomenon can generally avoid this misinterpretation. Passage of a feeding tube and partial filling of the bladder will also help clarify the anatomy. At the other extreme, bladder filling can cause compression or collapse of the ureterocele. In this instance, the bladder is visualized but the ureterocele is not seen. Further filling of the bladder may cause the extravesical prolapse of the ureterocele due to the lack of bladder wall backing. In this instance, the prolapsed or everted ureterocele may be mistaken for a bladder diverticulum. Partial bladder decompression and reimaging will help to avoid this misinterpretation. The best images are obtained when the bladder is partially filled allowing the dilated ureterocele to be surrounded by bladder urine and causing separation of ureterocele wall from the bladder wall.
Additional studies may also be necessary to help
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Treatment for ureterocele is very complex, individualized, and varies from child to child. Your pediatric urologist will discuss and outline the various options and determine which is best for your child based on:
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- the extent of the condition(s)
- your child's age, overall health, and medical history
- your child's tolerance for specific medications, procedures, or therapies
- expectations for the course of the condition(s)
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If your child is ill from a urinary tract infection, intravenous fluids and antibiotics may be administered. Once the urinary tract infection is resolved, the ureterocele will be addressed. Treatment of the ureterocele often depends on its size and the function of the kidney that the ureter is draining. If the area of the ureter has a great deal of urine accumulation, it may need to be surgically drained. Larger ureteroceles that may cause a great deal of reflux (or back-flow) into the ureter may need to be removed. If there is a duplicate ureter, the twin may be left intact. In some children, the kidney of the affected side may be damaged and part of it may need to be removed.
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Reseachers at Children's Hospital Boston's Center for Genitourinary Tissue Reconstruction are looking into ways to apply tissue engineering techniques to treat children with ureteroceles. Tissue engineering allows doctors to use the patients own cells to create tissue to augment the ureter in children with a ureteroceles who require more extensive reconstructive surgery. Doctors would be able to take a sample of cells from the patient's ureter, and grow it in the laboratory to create enough tissue help reconstruct the ureter.
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The information on this website should not be taken as medical advice, which can only be given to you by your personal health care professional. |
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