Geha Laboratory | Recent Publications

Allergic Diseases

Galand, C., Leyva-Castillo, J.M., Yoon, J., Han, A., Lee, M.S., McKenzie, A., Stassen, M., Oyoshi, M.K. and Geha, R.S. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J. All.Clin. Immunol. In Press

Oyoshi, M., Lewis, C.N., Beaupre, J., Venturelli, N., Zeigler. S. McKenzie, A and Geha, R.S. IL-33 and TSLP promotes the dissemination of cutaneously inoculated vaccinia virus. J. All. Clin. Immunol. 135:1511-8, 2015

Oyoshi, M., Lewis, C.N., Beaupre, J., Venturelli, N., Iwakura, Y., and Geha, R.S. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J. All. Clin. Immunol. 135, 1511-1518, 2015 

Oyoshi, M., He, R Li, Y., Mondal, S., Yoon, J., Afshar, R., Chen, M., Lee, D. M., Luo, H.R., Luster, A., Cho, J.S., Miller, L.S., Larson, A., Murphy, G. and R. S. Geha LTB4  driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 37:747-58, 2012

Oyoshi, M., He, R., Kanaoka, Y., ElKhal, A., Kawamoto, S., Calamito, M., Lewis, C. N., Austen, K.F., and R. S. Geha. Eosinophil-derived LTC4 signals via CysLT2R to promote skin thickening and collagen deposition in a mouse model of allergic skin inflammation. Proc Natl Acad Sci U S A. 109:4992-7, 2012

He, R., Oyoshi, M, Wang, JYT, Hodge, M., Jin, H., and Geha, R.S. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge.  J. All. Clin. Immunol. . 126: 784-790, 2010

Oyoshi, M., ElKhal, A., Kumar, L., Scott, J. E., Koduru, S., He, R., Leung, D.Y.M., Howell, M.D., Oettgen. H.C., Murphy, G.F., and R. S. Geha. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response Proc. Nat. Acad. Sci. USA. 106:14954-9, 2009

Jin, H,  Oyoshi, M., Mathias, C., Young, D., Collins, M., Grusby, M., Wenzel, J., Bieber4, T., Bianchi, T., Boes, M., Oettgen, H.C and R. S. Geha.  IL-21R is essential for the migration of dendritic cells from skin to draining lymph nodes and for the immune response to epicutaneous sensitization. J. Clin. Invest. 119; 47-60, 2009

He, R., Oyoshi, M., Garibyan, L., Kumar, L., Ziegler,. S. F. and R. S. Geha. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc. Nat. Acad. Sci. USA. 105:11875-8, 2008

Primary Immunodeficiency Diseases

Jabara, H. H.*, Boyden, E. S.*, Chou, J.*, Ramesh, N., Massaad, J., M., Benson, H., Bainter, W., Fraulino, D., Rashimov, F., Sieff, C., Liu, Z., Alishemmari, H., S., al-Ramadi, K., B., Al-Dekhri, H., Arnaout, R., Abishkair, M., Vatsayan, A., Siliver, E., Ahuja, S., Davies, G., Sola-Visner, M., Ohsumi, K., T., Andrews, C., N., Notarangelo, D., L., Felming, D., M., Al-Herz, W., Kunkel. M., L., and Geha, R. S. Immunodeficiency caused by a mutation in transferrin receptor 1. Nature Genetics. 48: 74-8, 2016. In Press

Mooster, M.L., Le Bras, S., MAssaad, M. J., Jabara, H. J., Yoon. J., Heesters, Galand, C., B.A., Burton, O.T., Mattoo, H., Manis, J., and Geha, R.S. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S321 mutation in IkBa.  J. Exp. Med. 212:185-202, 2015

Massaad, M., Oyoshi, M., Koduru, S., Kane, J., Alcaide, P., Nakamura, F., Ramesh, N., Luscinskas, W., Hartwig, J., and Geha, R.S.  Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Molecular and Cellular Biology 34:4343-54, 2014

Kumar, L. Chou, J., Yee, C.S.K., Borzutzky. A., Vollman, E., von Andrian, U., Park, S-Y, Hollander, G., Manis, J., Poliani, P.L., and R.S. Geha Leucine Rich Repeat Containing 8a (LRRC8a) is Essential for Lymphocyte Development and Function. J. Exp. Med. 211: 929-942, 2014

Janssen, E., Tsitsikov, E., Al-Herz, W., Lefranc, G., Dasouki, M., Bonilla, F. A., Chatila, T., Schneider, L., and Geha, R.S. Flow cytometry biomarkers distinguish DOCK8 deficiency from sever atopic detmatitis. Clinical Immunology. 150: 220-224, 2014.

Janssen, E., Ozcan, E., Liadaki, K., Jabara, H. H., Manis, J., Akira, S., Fitzgerald, K., Golenbock, G., R. S. Geha*, and. TRIF is essential for TLR4-driven IgE class switching. J. Immunol. 192: 2651-2658, 2014   

Jabara, H. H., Toshiro Ohsumi, T. Janet Chou, J., Massaad, M. J., Benson, B., Megarbane, A., Chouery, E., Mikhael, R., Gorka, O., Gewies, A., Portales, P., Nakayama, T., Hosokawa, H., Revy, P., Herrod, H., Le Deist, F., Lefranc, G., Ruland, J., and R. S. Geha. A Homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J. All. Clin. Immunol. 132: 151-158, 2013

Jabara H., MacDonald D, Janssen, E., Massaad, M. J. Ramesh, N., Borzutzky, A., Rauter, I. Benson, H. Schneider, L., Baxi, S., Rechter, M., Notarangelo, L., Wakim, R., Dbaibo, G. Dasouki, M., Al-Herz, W., Barlan, I, Baris, S., Kutukculer, N., Ochs, H., Plebani, A., Kanariou, M, Lefranc, G., Reisli, I., Fitzgerald, K., Golenbock, D., Manis D., Keles, S, Baris, S., Ceja, R., Chatila, T., and R.S. Geha DOCK8 functions as an adaptor that links TLR/MyD88 signaling to B cell activation. Nature Immunology. 13: 612, 2012